Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment.
نویسندگان
چکیده
Short stature is a characteristic feature of pycnodysostosis. We report defective growth hormone secretion in response to provocation and low insulin-like growth factor-I (IGF-I) concentration in five out of six patients with pycnodysostosis. Physiological replacement with growth hormone increased IGF-I concentration and improved linear growth in these children.
منابع مشابه
Effect of Growth Hormone treatment on Height Velocity of Children with Pycnodysotosis
OBJECTIVE Pycnodysostosis is a rare autosomal recessive osteochondrodysplasia resulting from osteoclast dysfunction. Growth hormone (GH) secretion impairment and low insulin growth factor 1 (IGF-I) concentrations have been reported in these patients. The present study aims to describe GH effect on linear growth of eight children with pycnodysostosis. METHODS This study was conducted on 8 chil...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 75 3 شماره
صفحات -
تاریخ انتشار 1996